CD152 Antibody [UC10-4F10-11] (APC)
| Code | Size | Price |
|---|
| PSI-76-855-0.1mg | 0.1mg | £536.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: Armenian Hamster IgG
Antibody Clonality: Monoclonal
Antibody Clone: UC10-4F10-11
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
Cd152, Ly-56, Ctla-4, Ctla4
Background:
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
Background References:
- Herling, M., Teitell, M. A., Shen, R. R., Medeiros, L. J., Jones, D. (2003). TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin.Blood,101(12), 5007-5009.
- Peduzzi, E., Groeper, C., Schtte, D., Zajac, P., Rondini, S., Mensah-Quainoo, E., ... Daubenberger, C. A. (2007). Local activation of the innate immune system in Buruli ulcer lesions.Journal of Investigative Dermatology,127(3), 638-645.
- Sun, Q., Woodcock, J. M., Rapoport, A., Stomski, F. C., Korpelainen, E. I., Bagley, C. J., ... Lopez, A. F. (1996). Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.Blood,87(1), 83-92.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12477
NCBI Official Name:
cytotoxic T-lymphocyte-associated protein 4
NCBI Official Symbol:
Ctla4
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152.
Swissprot #:
P09793
User NOte:
Optimal dilutions for each application to be determined by the researcher.