CD8a Antibody [2.43] (APC)
| Code | Size | Price |
|---|
| PSI-76-657-0.1mg | 0.1mg | £560.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 2.43
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
Ly-2, Ly-B, Ly-35, Lyt-2, BB154331, Cd8a
Background:
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen. CD8a (the alpha chains) form heterodimers with CD8b (the beta chains) or homodimers (alpha-alpha), which occur as receptors on the surface of the majority of thymocytes. A subpopulation of mature T lymphocytes expresses the CD8 alpha beta (alpha beta TCR T cells), and a subpopulation of intestinal intraepithelial lymphocytes and dendritic cells express CD8a without CD8b. CD8 interacts with the mouse major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells.
Background References:
- Hirji, N., Lin, T. J., Bissonnette, E., Belosevic, M., Befus, A. D. (1998). Mechanisms of macrophage stimulation through CD8: macrophage CD8alpha and CD8-beta induce nitric oxide production and associated killing of the parasite Leishmania major.The Journal of Immunology,160(12), 6004-6011.
- Hirji, N., Lin, T. J., Befus, A. D. (1997). A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production.The Journal of Immunology,158(4), 1833-1840.
- TorresNagel, N., Kraus, E., Brown, M. H., Tiefenthaler, G., Mitnacht, R., Williams, A. F., Hnig, T. (1992). Differential thymus dependence of rat CD8 isoform expression.European journal of immunology,22(11), 2841-2848.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12525
NCBI Official Name:
CD8 antigen, alpha chain
NCBI Official Symbol:
Cd8a
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The 2.43 monoclonal antibody specifically reacts with mouse CD8 antigen.
Swissprot #:
P01731
User NOte:
Optimal dilutions for each application to be determined by the researcher.