CD252 Antibody [RM134L] (APC)
| Code | Size | Price |
|---|
| PSI-76-943-0.1mg | 0.1mg | £469.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: RM134L
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
Ath1, gp34, Ath-1, Ox40l, TXGP1, CD134L, OX-40L, Txgp1l, Tnfsf4
Background:
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.
Background References:
- Otsuki, N., Kamimura, Y., Hashiguchi, M., Azuma, M. (2006). Expression and function of the B and T lymphocyte attenuator (BTLA/CD272) on human T cells.Biochemical and biophysical research communications,344(4), 1121-1127.
- Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., ... Murphy, K. M. (2003). BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1.Nature immunology,4(7), 670-679.
- Sedy, J. R., Gavrieli, M., Potter, K. G., Hurchla, M. A., Lindsley, R. C., Hildner, K., ... Murphy, K. M. (2005). B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator.Nature immunology,6(1), 90-98.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
APC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
22164
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 4
NCBI Official Symbol:
Tnfsf4
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells.
Swissprot #:
P43488
User NOte:
Optimal dilutions for each application to be determined by the researcher.