CD252 Antibody [RM134L] (Biotin)
| Code | Size | Price |
|---|
| PSI-76-941-0.1mg | 0.1mg | £469.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: RM134L
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
Ath1, gp34, Ath-1, Ox40l, TXGP1, CD134L, OX-40L, Txgp1l, Tnfsf4
Background:
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells. On activated B cells it enhances immunoglobulin secretion and cell proliferation. CD252 is also known as the OX-40 ligand and interacts with the OX-40 antigen found on the surface of activated T cells. The RML134L is reported to block the costimulatory activity of OX-40L.
Background References:
- Stber, E., Neurath, M., Calderhead, D., Perry Fell, H., Strober, W. (1995). Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells.Immunity,2(5), 507-521.
- Akiba, H., Oshima, H., Takeda, K., Atsuta, M., Nakano, H., Nakajima, A., ... Okumura, K. (1999). CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells.The Journal of Immunology,162(12), 7058-7066.
- Calderhead, D. M., Buhlmann, J. E., Van den Eertwegh, A. J., Claassen, E., Noelle, R. J., Fell, H. P. (1993). Cloning of mouse Ox40: a T cell activation marker that may mediate TB cell interactions.The Journal of Immunology,151(10), 5261-5271.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
Biotin
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
22164
NCBI Official Name:
tumor necrosis factor (ligand) superfamily, member 4
NCBI Official Symbol:
Tnfsf4
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted biotin was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The RM134L monoclonal antibody specifically reacts with mouse CD252, a TNF/NGF superfamily member present on activated B lymphocytes and antigen-presenting cells.
Swissprot #:
P43488
User NOte:
Optimal dilutions for each application to be determined by the researcher.