CD16 Antibody [2.4G2] (FITC)
| Code | Size | Price |
|---|
| PSI-76-579-0.025mg | 0.025mg | £264.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 2.4G2
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
Fcgr3, Fcgr3
Background:
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc gamma I receptor.
Background References:
- Choi, E. I., Wang, R., Peterson, L., Letvin, N. L., Reimann, K. A. (2008). Use of an antiCD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.Immunology,124(2), 215-222.
- Perussia, B. I. C. E., Trinchieri, G. I. O. R. G. I. O. (1984). Antibody 3G8, specific for the human neutrophil Fc receptor, reacts with natural killer cells.The Journal of Immunology,132(3), 1410-1415.
- Vossebeld, P. J., Homburg, C. H., Roos, D., Verhoeven, A. J. (1997). The anti-Fc-gamma RIII mAb 3G8 induces neutrophil activation via a cooperative action of Fc-gamma RIIIb and Fc-gamma RIIa.The international journal of biochemistry cell biology,29(3), 465-473.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
FITC
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
14131
NCBI Official Name:
Fc receptor, IgG, low affinity III
NCBI Official Symbol:
Fcgr3
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Innate Immunity
SPECIFICITY:
The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc gamma III) and CD 32 (Fc gamma II).
Swissprot #:
P08508
User NOte:
Optimal dilutions for each application to be determined by the researcher.