CD19 Antibody [1D3] (PE)
| Code | Size | Price |
|---|
| PSI-76-780-0.1mg | 0.1mg | £404.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 1D3
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
AW495831, Cd19
Background:
The 1D3 monoclonal antibody specifically reacts with mouse CD19, a 95 kDa transmembrane glycoprotein, a member of the Ig superfamily and a B cell-lineage differentiation antigen expressed by all the B lymphocyte development stages, except for the terminally differentiated plasma cells. CD19 associates with CD21, CD81 and MHC class II to form a multi-molecular complex that initiates the mature B lymphocyte activation by interaction with the B-cell receptors. CD 19 enhances the B cell proliferation, development and activation, and the maturation of memory B cells. In CD19-deficient mice, the generation and maturation of B lymphocytes in the bone marrow and periphery are affected.
Background References:
- Cherukuri, A., Cheng, P. C., Pierce, S. K. (2001). The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens.The Journal of Immunology, 167(1), 163-172.
- Krop, I., De Fougerolles, A. R., Hardy, R. R., Allison, M., Schlissel, M. S., Fearon, D. T. (1996). Self-renewal of B-1 lymphocytes is dependent on CD19.European journal of immunology,26(1), 238-242.
- Engel, P., Zhou, L. J., Ord, D. C., Sato, S., Koller, B., Tedder, T. F. (1995). Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule.Immunity,3(1), 39-50.
- Sato, S., Jansen, P. J., Tedder, T. F. (1997). CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.Proceedings of the National Academy of Sciences,94(24), 13158-13162.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
12478
NCBI Official Name:
CD19 antigen
NCBI Official Symbol:
Cd19
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The 1D3 monoclonal antibody specifically reacts with mouse CD19, a 95 kDa transmembrane glycoprotein, a member of the Ig superfamily and a B cell-lineage differentiation antigen expressed by all the B lymphocyte development stages, except for the terminally differentiated plasma cells.
Swissprot #:
P25918
User NOte:
Optimal dilutions for each application to be determined by the researcher.