CD274 Antibody [10F.9G2] (PE)
| Code | Size | Price |
|---|
| PSI-76-960-0.1mg | 0.1mg | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: 10F.9G2
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Documents
Further Information
Additional Names:
B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1, CD274
Background:
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily. CD274 is expressed on the B and T lymphocytes, natural killer cells, and dendritic cells. The receptor for the B7-H1 molecule is PD-1, which contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM), and is expressed on activated B and T cells. The interaction between CD274 and PD-1 seems to downregulate the T and B immune responses.
Background References:
- Akashi, S., Ogata, H., Kirikae, F., Kirikae, T., Kawasaki, K., Nishijima, M., ... Miyake, K. (2000). Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2.Biochemical and biophysical research communications,268(1), 172-177.
- Shimazu, R., Akashi, S., Ogata, H., Nagai, Y., Fukudome, K., Miyake, K., Kimoto, M. (1999). MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.The Journal of experimental medicine,189(11), 1777-1782.
- Mirlashari, M. R., Lyberg, T. (2003). Expression and involvement of Toll-like receptors (TLR) 2, TLR4, and CD14 in monocyte TNF-alpha production induced by lipopolysaccharides from Neisseria meningitidis.Medical science monitor: international medical journal of experimental and clinical research,9(8), BR316-24.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
PE
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
29126
NCBI Official Name:
CD274 molecule
NCBI Official Symbol:
CD274
NCBI Organism:
Homo sapiens
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Immunology
SPECIFICITY:
The 10F.9G2 monoclonal antibody specifically reacts with mouse CD274, also known as B7-H1 or PD-L1, a 43 kDa glycoprotein of the B7 family of the immunoglobulin superfamily.
Swissprot #:
Q9NZQ7
User NOte:
Optimal dilutions for each application to be determined by the researcher.