CD49b Antibody [HMa2]
| Code | Size | Price |
|---|
| PSI-76-807-0.05mg | 0.05mg | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: Armenian Hamster IgG
Antibody Clonality: Monoclonal
Antibody Clone: HMa2
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
DX5, CD49B, Itga2
Background:
The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1). VLA-2 is expressed on NK-T cells, epithelial cells, platelets, and CD+4 T lymphocytes. It is the receptor for laminin and collagen and is upregulated in response to mitogens. The Hma2 antibody is reported to partially block the interaction with collagen in T cells, but not NK cells.
Background References:
- Baron, J. L., Reich, E. P., Visintin, I., Janeway Jr, C. A. (1994). The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1.Journal of Clinical Investigation,93(4), 1700.
- Chisholm, P. L., Williams, C. A., Lobb, R. R. (1993). Monoclonal antibodies to the integrin alpha 4 subunit inhibit the murine contact hypersensitivity response.European journal of immunology,23(3), 682-688.
- Holzmann, B., McIntyre, B. W., Weissman, I. L. (1989). Identification of a murine Peyer's patchspecific lymphocyte homing receptor as an integrin molecule with an alpha chain homologous to human VLA-4alpha .Cell,56(1), 37-46.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
16398
NCBI Official Name:
integrin alpha 2
NCBI Official Symbol:
Itga2
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The HMa2 monoclonal antibody specifically reacts with mouse CD49b (integrin alpha 2), a 150kDA transmembrane glycoprotein that forms the VLA-2 complex with CD29 (integrin beta 1).
Swissprot #:
Q62469
User NOte:
Optimal dilutions for each application to be determined by the researcher.