CD11a Antibody [M17/4]
| Code | Size | Price |
|---|
| PSI-76-138-0.1mg | 0.1mg | £433.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2a, kappa
Antibody Clonality: Monoclonal
Antibody Clone: M17/4
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
Cd11a, LFA-1, Ly-15, Ly-21, (p180), LFA-1A, Itgal
Background:
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein. CD11a is the integrin alpha L chain that forms with CD18 the heterodimer molecule Lymphocyte Function-associated Antigen-1 (LFA-1). LFA-1 is expressed on all leukocytes and is involved in intercellular adhesions. The M17/4 antibody blocks many of the LFA-1 mediated cell interaction and in vivo it prolongs allograft survival, inhibits the autoimmune response, and reduces graft versus host reactions.
Background References:
- Saban, M. R., Saban, R., Bjorling, D., Haak-Frendscho, M. (1997). Involvement of leukotrienes, TNF-alpha, and the LFA-1/ICAM-1 interaction in substance P-induced granulocyte infiltration.Journal of leukocyte biology,61(4), 445-451.
- Zhao, Y., Iwata, M. (1995). Cross-linking of the TCRCD3 complex with CD4, CD8 or LFA-1 induces an anti-apoptotic signal in thymocytes: the signal is canceled by FK506.International immunology,7(9), 1387-1396.
- Kootstra, C. J., Van Der Giezen, D. M., Van Krieken, J. H. J. M., De Heer, E., Bruijn, J. A. (1997). Effective treatment of experimental lupus nephritis by combined administration of antiCD11a and antiCD54 antibodies.Clinical Experimental Immunology,108(2), 324-332.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
16408
NCBI Official Name:
integrin alpha L
NCBI Official Symbol:
Itgal
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Cancer,Functional Assays
SPECIFICITY:
The M17/4 monoclonal antibody specifically reacts with mouse CD11a, a 180kDA glycoprotein.
Swissprot #:
P24063
User NOte:
Optimal dilutions for each application to be determined by the researcher.