CD70 Antibody [FR70]
| Code | Size | Price |
|---|
| PSI-76-032-0.05mg | 0.05mg | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: Rat IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: FR70
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
Cd27l, CD27LG, Tnfsf7, Cd70
Background:
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
Background References:
- Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology,159(10), 4959-4965.
- Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb.International immunology,10(4), 517-526.
- Bullock, T. N., Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology,174(2), 710-717.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
21948
NCBI Official Name:
CD70 antigen
NCBI Official Symbol:
Cd70
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily.
Swissprot #:
O55237
User NOte:
Optimal dilutions for each application to be determined by the researcher.