CD117 Antibody [ACK2]

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ProSci
Product Code: PSI-76-895
Product Group: Primary Antibodies
Supplier: ProSci
CodeSizePrice
PSI-76-895-0.1mg0.1mg£348.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rat
Antibody Isotype: Rat IgG2b, kappa
Antibody Clonality: Monoclonal
Antibody Clone: ACK2
Regulatory Status: RUO
Target Species: Mouse
Applications:
  • Flow Cytometry
  • Functional Study
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Storage:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Documents

Further Information

Additional Names:
W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, CD117, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, Kit
Background:
The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.
Background References:
  • Godfrey, D. I., Kennedy, J., Mombaerts, P., Tonegawa, S., Zlotnik, A. (1994). Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8-thymocyte differentiation. The Journal of Immunology,152(10), 4783-4792.
  • Godfrey, D. I., Zlotnik, A. L. B. E. R. T., Suda, T. A. K. A. S. H. I. (1992). Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.The Journal of Immunology,149(7), 2281-2285.
  • Feng, H., Sandlow, J. I., Sandra, A. (1998). The c-kit receptor and its possible signaling transduction pathway in mouse spermatozoa.Molecular reproduction and development,49(3), 317-326.
Buffer:
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
16590
NCBI Official Name:
kit oncogene
NCBI Official Symbol:
Kit
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Area:
Cancer,Functional Assays
SPECIFICITY:
The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene.
Swissprot #:
P05532
User NOte:
Optimal dilutions for each application to be determined by the researcher.