CD61 Antibody [2C9.G3]
| Code | Size | Price |
|---|
| PSI-76-181-0.05mg | 0.05mg | £344.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: Armenian Hamster IgG
Antibody Clonality: Monoclonal
Antibody Clone: 2C9.G3
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Applications:
- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
CD61, GP3A, INGRB3, Itgb3
Background:
The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51. The complex binds to other ligands such as fibrinogen, fibronectin, thrombospondin, and von WIllebrand factor. It is expressed by granulocytes, platelets, activated T cells, smooth muscle, and a subset of B cells.
Background References:
- Vaillant, F., Asselin-Labat, M. L., Shackleton, M., Forrest, N. C., Lindeman, G. J., Visvader, J. E. (2008). The mammary progenitor marker CD61/-beta 3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis.Cancer research,68(19), 7711-7717.
- Yasuda, M., Hasunuma, Y., Adachi, H., Sekine, C., Sakanishi, T., Hashimoto, H., ... Okumura, K. (1995). Expression and function of fibronectin binding integrins on rat mast cells.International immunology,7(2), 251-258.
- Wu, X., Mogford, J. E., Platts, S. H., Davis, G. E., Meininger, G. A., Davis, M. J. (1998). Modulation of calcium current in arteriolar smooth muscle by alpha v-beta 3 and alpha 5-beta 1 integrin ligands.The Journal of cell biology,143(1), 241-252.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
16416
NCBI Official Name:
integrin beta 3
NCBI Official Symbol:
Itgb3
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The 2C9.G3 monoclonal antibody specifically reacts with the mouse/rat CD61 molecule, known as the integrin beta 3 that forms the vitronectin receptor with CD51.
Swissprot #:
O54890
User NOte:
Optimal dilutions for each application to be determined by the researcher.