CD40 Antibody [HM40-3]
| Code | Size | Price |
|---|
| PSI-76-026-0.5mg | 0.5mg | £633.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: Armenian Hamster IgM, kappa
Antibody Clonality: Monoclonal
Antibody Clone: HM40-3
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Applications:
- Flow Cytometry
- Functional Study
Storage:
The product should be stored undiluted at 4°C. Do not freeze.
Documents
Further Information
Additional Names:
IGM, p50, Bp50, GP39, IMD3, TRAP, HIGM1, T-BAM, Tnfrsf5, AI326936, Cd40
Background:
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.
Background References:
- Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., Shirai, T. (1996). CD40mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus.European journal of immunology,26(12), 3061-3065.
- Ferlin, W. G., Severinson, E., Strm, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., Howard, M. C. (1996). CD40 signaling induces interleukin4independent IgE switching in vivo.European journal of immunology,26(12), 2911-2915.
- Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., Takemori, T. (1996). Activation of mitogenactivated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.European journal of immunology,26(7), 1451-1458.
Buffer:
Phosphate-buffered aqueous solution, ph7.2.
Concentration:
batch dependent
Conjugate:
Unconjugated
DISCLAIMER:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
NCBI Gene ID #:
21939
NCBI Official Name:
CD40 antigen
NCBI Official Symbol:
Cd40
NCBI Organism:
Mus musculus
Physical State:
liquid
Purification:
The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/?g of the protein.
Research Area:
Immunology,Functional Assays
SPECIFICITY:
The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50.
Swissprot #:
P27512
User NOte:
Optimal dilutions for each application to be determined by the researcher.