Beta 2 microglobulin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-039-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Cynomolgus Monkey
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
B2M
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
Background References:
- G?ssow D., et al., 1987, J. Immunol. 139 (9): 3132?8.
- Gorevic P.D., et al., 1986, Proc. Natl. Acad. Sci. U.S.A. 83:7908-7912.
- Argiles A., et al., 1992, Nephrol. Dial. Transplant. 7:1106-1110.
- Momoi T., et al., 1995, Clin. Chim. Acta 236:135-144.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
712428
NCBI Official Name:
beta-2-microglobulin
NCBI Official Symbol:
B2M
NCBI Organism:
Macaca mulatta
Physical State:
Lyophilized
Predicted Molecular Weight:
12.5 kDa
Protein Accession #:
Q6V7J5
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q6V7J5