PDL1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-594-0.1mg | 0.1mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Cynomolgus Monkey
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
Background References:
- Dong H., et al., 1999, Nat. Med. 5:1365-1369. (2) Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034. (3) Nishimura H., et al., 2001, Trends?in?Immunology?22:265.?
- Freeman G.J., et al., 2000, J. Exp. Med. 192:1027-1034.
- Nishimura H., et al., 2001, Trends?in?Immunology?22:265.?
Biological Activity:
Immobilized Cynomolgus PD-L1, His Tag at 10 ug/mL (100 ul/well) can bind Cynomolgus PD-1, Fc Tag with a linear range of 0.6-10 ug/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
27.1 kDa
Protein Accession #:
F6VEW6
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
F6VEW6