IL1 R2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-437-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD121b, IL1RB, IL1R2, CDw121b
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Background References:
- Liu C., et al., 1996, J. Biol. Chem. 271:20965-20972.
- Giri J.G., et al., 1994, J. Immunol. 153:5802-5809.
- Symons J.A., et al., 1995, Proc. Natl. Acad. Sci. U.S.A. 92:1714-1718.
- Orlando S., et al., 1997, J. Biol. Chem. 272:31764-31769.
Biological Activity:
Measured by its binding ability in a functional ELISA.Immobilized Human IL-1 RII, Fc Tag at 10 μg/ml (100 μL/well),can bind Biotinylated Human IL-1 alpha with a linear range of 0.05-1 μg/ml.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
7850
NCBI Official Name:
interleukin 1 receptor, type II
NCBI Official Symbol:
IL1R2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
64 kDa
Protein Accession #:
NP_004624.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P27930