CD200 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-574-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD200, MOX1, MOX2, MRC, OX-2, My033
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD200 is also known as OX-2 membrane glycoprotein (OX-2), is a type-1 membrane glycoprotein, which contains two immunoglobulin domains (1 Ig-like C2-type (immunoglobulin-like) domain and Ig-like V-type (immunoglobulin-like) domain), and thus belongs to the immunoglobulin superfamily. CD200 / OX-2 is widely expressed in multiple cell types. CD200 interacts with a structurally related receptor (CD200R) expressed mainly on myeloid cells and is involved in regulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via their respective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion.
Background References:
- McCaughan, G.W. et al., 1987, Immunogenetics 25:329-335.
- Chen, Z. et al., 2006, Mol Immunol. 43 (6): 579-587.
- Wright GJ., et al., 2003, J. Immunol. 171 (6): 3034?46.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD200R1 at 2μg/ml,the concentration of rhCD200 Fc Chimera that produces 50% of the optimal binding response is appoximately 2. 0-16 ng/mL.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
4345
NCBI Official Name:
CD200 molecule
NCBI Official Symbol:
CD200
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
48.6 kDa
Protein Accession #:
AAH22522
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P41217