CD273 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-616-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Background References:
- Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846.
- Latchman Y., et al., 2001, Nat. Immunol. 2:261-268.
- He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.
Biological Activity:
(1) Measured by its binding ability in a functional ELISA. Immobilized Human PD-1, Strep Tag at 2 ug/mL (100 ul/well) can bind Human PD-L2, Fc Tag with a linear range of 0.4-3 ng/mL. (2) Measured by its binding ability in a functional ELISA. Immobilized Human PD-1, His Tag at 0.2 ug/mL (100 ul/well) can bind Human PD-L2, Fc Tag with a linear range of 0.16-2.5 ug/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
80380
NCBI Official Name:
programmed cell death 1 ligand 2
NCBI Official Symbol:
PDCD1LG2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
49.2 kDa
Protein Accession #:
AAI13679
Purity:
>95% as determined by SDS-PAGE more than 90% measured by SEC-HPLC.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9BQ51