LILRB1 Recombinant Protein

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ProSci
Product Code: PSI-96-175
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-96-175-0.1mg0.1mg£597.00
Quantity:
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Overview

Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

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Further Information

Additional Names:
CD85J, LILRB1, CD85, ILT2, LIR1, MIR7
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD85 antigen-like family member J (CD85J) is also known as Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1 or LIR-1), Immunoglobulin-like transcript 2 (ILT-2), Monocyte/macrophage immunoglobulin-like receptor 7 (MIR7), which belongs to leukocyte immunoglobulin-like receptor (LIR) family. CD85J / LILRB1 Contains 4 Ig-like C2-type (immunoglobulin-like) domains. CD85J / LIR-1 is expressed predominantly on B-cells and monocytes. CD85J is receptor for class I MHC antigens and recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles and is also receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. CD85J / LILRB1 interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. CD85J / LILRB1 inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Background References:
  • Cosman D., et al., 1997, Immunity 7:273-282.
  • Fanger N.A., et al., 1998, Eur. J. Immunol. 28:3423-3434.
  • Chapman T.L., et al., 1999, Immunity 11:603-613.
  • Bellon T., et al., 2002, J. Immunol. 168:3351-3359.
Buffer:
50 mM tris, 100 mM glycine, pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
10859
NCBI Official Name:
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
NCBI Official Symbol:
LILRB1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
73.8 kDa
Protein Accession #:
NP_006660
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8NHL6