HER4 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-286-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
HER4, ErbB4, MGC138404, p180erbB4
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Receptor tyrosine-protein kinase erbB-4 (ErbB4) is also known as Her4, is a single-pass type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ERBB4 contains multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and betacellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. ERBB4 has been shown to interact with: DLG4, NRG1, STAT5A and YAP1. Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.
Background References:
- Garcia R A., et al., 2000, (UNITED STATES) 97 (7): 3596?601.
- Huang, Y Z., et al., 2000, Neuron (UNITED STATES) 26 (2): 443?55.
- Williams Christopher C., et al., 2004, J. Cell Biol. (United States) 167 (3): 469?78.
- Schulze Waltraud X., et al., 2005, Mol. Syst. Biol. (England) 1 (1): 2005.0008.
Buffer:
PBS, pH7.4
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
2066
NCBI Official Name:
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
NCBI Official Symbol:
ERBB4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
96 kDa
Protein Accession #:
NP_001036064.1
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q15303