LEPR Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-513-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
LEPR, CD295, DKFZp686B1731, OBR, Leptin receptor
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Leptin receptor (LEPR) is also known as LEP-R, cluster of differentiation 295 (CD295), OB-R and B219, is a single-transmembrane-domain receptor of the gp130 family of cytokine receptors. Leptin receptor exists as homodimer and binds Leptin with high affinity, thus mediates the biological function of the adipocyte-specific hormone Leptin. LEPR is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this protein have been associated with obesity and pituitary dysfunction. Interaction of leptin and leptin receptor is crucial for body weight and bone mass regulation in mammals through hypothalamic effects on satiety and energy expenditure. Meanwhile, research data supports a leptin receptor activation model based on ligand-induced conformational changes.
Background References:
- Tutino V, et al., 2011, Anticancer Res., 31(10):3381-3.
- Xu YJ., et al., 2011, J Cancer Res Clin Oncol., 137(12):1841-8.
- Sharma K, et al., 2003, Am. J. Physiol. Renal Physiol. 284 (6): F1138?44.
Buffer:
PBS, pH7.4
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
3953
NCBI Official Name:
leptin receptor
NCBI Official Symbol:
LEPR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
121 kDa
Protein Accession #:
NP_002294.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P48357