LIFR Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-522-0.2mg | 0.2mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
LIFR, CD118, FLJ98106, FLJ99923, SJS2, STWS, SWS
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Leukemia inhibitory factor receptor is also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.
Background References:
- Timmermann, Andreas, et al. 2002, Eur. J. Biochem. (Germany) 269 (11): 2716?26.
- Gearing, D.P. et al.,1991, EMBO J. 10 (10): 2839-2848.
- Gearing, D.P. et al.,1992, New Biol. 4 (1): 61-65.
- Mosley, B. et al.,1996, J. Biol. Chem. 271 (51): 32635-32643.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human LIF, Tag Free at 0.2ug/mL (100 uL/well) can bind Human LIF R, Fc Tag with a linear range of 7.8-31.25 ng/mL.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
3977
NCBI Official Name:
leukemia inhibitory factor receptor alpha
NCBI Official Symbol:
LIFR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
115.5 kDa
Protein Accession #:
NP_001121143
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P42702