Jagged 1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-482-0.05mg | 0.05mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CD339, JAG1, Jagged1, hJ1, JAGL1
Background:
Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).
Background References:
- Li L., et al., 1998, Immunity 8:43-55.
- Bash J., et al., 1999, EMBO J. 18:2803-2811.
- Zimrin A.B., et al., 1996, J. Biol. Chem. 271:32499-32502.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
182
NCBI Official Name:
jagged 1
NCBI Official Symbol:
JAG1
NCBI Organism:
homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
112.3 kDa
Protein Accession #:
NP_000205
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P78504