PVR Recombinant Protein

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ProSci
Product Code: PSI-96-116
Product Group: Recombinant Proteins
Supplier: ProSci
CodeSizePrice
PSI-96-116-0.1mg0.1mg£626.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Regulatory Status: RUO
Target Species: Human
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Documents

Further Information

Additional Names:
PVR, FLJ25946, PVS, CD155, TAGE4, HVED, NECL5
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155/PVR was originally isolated based on its ability to mediate polio virus attachment to host cells. The fulllength (or CD155 alpha isoform) is synthesized as a 417 amino acid (aa) precursor that contains a 20 aa signal sequence, a 323 aa extracellular region, a 24 aa TM segment and a 50 aa cytoplasmic tail. The extracellular region contains one N terminal V type and two C2 type Ig like domains. CD155 is a transmembrane protein with 3 extracellular immunoglobulin-like domains, D1-D3, where D1 is recognized by the virus. Low resolution structures of CD155 complexed with poliovirus have been obtained using electron microscopy while a high resolution structures of theectodomain D1 and D2 of CD155 were solved by x-ray crystallography.
Background References:
  • Mendelsohn CL, Wimmer E, Racaniello VR, 1989, Cell 56 (5): 855?65 .
  • Maier MK, Seth S, Czeloth N, et al., 2007, European Journal of Immunology 37 (8): 2214.
  • Koike, H. et al., 1990, EMBO J. 9:3217.
  • Zhang P, Mueller S, Morais MC. Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18284?9.
Biological Activity:
Measure by its ability to bind with recombinant human DNAM1 / CD226 in a functional ELISA assay.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
5817
NCBI Official Name:
poliovirus receptor
NCBI Official Symbol:
PVR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
28 kDa
Protein Accession #:
NP_006496.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P15151