CNTFR alpha Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-194-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CNTFR, CNTF R alpha
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Ciliary neurotrophic factor receptor subunit alpha (CNTFR or CNTFR-alpha) belongs to the type I cytokine receptor family and type 3 subfamily. CNTFR contains two fibronectin type-III domains and one Ig-like C2-type (immunoglobulin-like) domain. This receptor and its cognate ligand support the survival of neurons. This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.
Background References:
- Davis S., et al., 1991, Science 253 (5015): 59?63.
- Sleeman MW., et al., 2000, Pharm Acta Helv 74 (2?3): 265?72.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized human CTNFR at 10μg/ml (100μl/well) can bind biotinylated human CNTF with a linear ranger of 3. 2 - 100 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
1271
NCBI Official Name:
ciliary neurotrophic factor receptor
NCBI Official Symbol:
CNTFR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
36.9 kDa
Protein Accession #:
AAH01492
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P26992