Poly Ig receptor Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-627-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PIGR, Poly-Ig receptor
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
Background References:
- Krajci P., et al., 1991, Hum. Genet. 87:642-648.
- Eiffert H., et al., 1984, Hoppe-Seyler's Z. Physiol. Chem. 365:1489-1495.
- Hughes G.J., et al., 1997, FEBS Lett. 410:443-446.
- Hamburger A.E., et al., 2004, Structure 12:1925-1935.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
5284
NCBI Official Name:
polymeric immunoglobulin receptor
NCBI Official Symbol:
PIGR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
68.7 kDa
Protein Accession #:
AAI10495.1
Purity:
>98% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P01833