S100B Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-670-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
S100B, NEF, S100, S100beta
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Background References:
- Yamaguchi F., et al., 2012, J. Biol. Chem. 287:13787-13798.
- Smith S.P., et al., 1998, Structure 6:211-222.
- McClintock K.A., et al., 2003, J. Biol. Chem. 278:6251-6257.
Buffer:
50 mM Tris, 150 mM NaCl,pH8.0
Fusion Tag:
His Tag
NCBI Gene ID #:
6285
NCBI Official Name:
S100 calcium binding protein B
NCBI Official Symbol:
S100B
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
11.5 kDa
Protein Accession #:
NP_006263
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P04271