VLDLR Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-778-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
VLDLR, RP11-320E16.1, CHRMQ1, FLJ35024, VLDLRCH, VLDL receptor
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
The very-low-density-lipoprotein receptor (VLDL-R) is a lipoprotein receptor that shows considerable similarity to the lowdensity-lipoprotein receptor. VLDL R is a 130 kDa type I transmembrane protein in the LDL receptor family that plays a significant role in lipid metabolism and in nervous system development and function .This receptor has been suggested to be important for the metabolism of apoprotein-E-containing triacylglycerol-rich lipoproteins, such as very-low-densitylipoprotein (VLDL), beta-migrating VLDL and intermediate-density lipoprotein. It is also one of the receptors of reelin, an extracellular matrix protein which regulates the processes of neuronal migration and synaptic plasticity. In humans, the VLDL-R is encoded by the VLDLR gene.
A rare neurological disorder first described in the 1970s under the name "disequilibrium syndrome" is now considered to be caused by the disruption of VLDLR gene. The disorder was renamed VLDLR-associated cerebellar hypoplasia (VLDLRCH) after a 2005 study. It is associated with parental consanguinity and found in secluded communities such as the Hutterites. VLDLRCH is one of the two known genetic disorders caused by a disruption of reelin signaling pathway, along with Norman-Roberts syndrome.
Background References:
- Sakai J, Hoshino A, Takahashi S, et al., 269 (3): 2173?82.
- Moheb LA, Tzschach A, Garshasbi M, et al. Eur. J. Hum. Genet. 16 (2): 270?3.
- Boycott KM, Flavelle S, Bureau A, et al., 2005, Am. J. Hum. Genet. 77 (3): 477?83.
Biological Activity:
Measured by its binding ability in a functional ELISA. When Recombinant Human Apolipoprotein E3 is immobilized at 1μg/ml (100μl/well), the concentration of Recombinant Human VLDLR that produces 50% of the optimal binding response is found to be approximately 0. 03 - 0. 15μg/ml.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
7436
NCBI Official Name:
very low density lipoprotein receptor
NCBI Official Symbol:
VLDLR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
83 kDa, The protein migrates as 110-120 kDa under reducing (R) condition (SDS-Page) due to different glycosylation.
Protein Accession #:
AAI42654
Purity:
>97% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P98155