ANGPTL3 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-027-0.1mg | 0.1mg | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ANGPTL3, ANGPT5, ANG-5, Angiopoietin-5, FHBL2
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
Background References:
- Conklin D., et al., 1999, Genomics 62:477-482.
- Musunuru K., et al., 2010, New England Journal of Medicine 363 (23): 2220?2227.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
27329
NCBI Official Name:
angiopoietin-like 3
NCBI Official Symbol:
ANGPTL3
NCBI Organism:
homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
24.6 kDa
Protein Accession #:
NP_055310
Purity:
>95% as determined by reduced SDS-PAGE.
Less than 1.0 EU per ug by the LAL method.
Less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q9Y5C1