VTCN1 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-049-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
B7-H4, VTCN1, B7S1, B7h.5
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
Background References:
- Salceda S., et al., 2005, Exp. Cell Res. 306:128-141.
- Kryczek I., et al., 2006, J. Exp. Med. 203:871-881.
- Miyatake T., et al., 2007, Gynecol. Oncol. 106:119-127.
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized Human B7-H4, His Tag at 2 ug/mL can bind anti-B7-H4 mAb (Human IgG1) with a linear range of 0.4-6 ng/mL.
Buffer:
PBS, pH 7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
79679
NCBI Official Name:
V-set domain containing T cell activation inhibitor 1
NCBI Official Symbol:
VTCN1
NCBI Organism:
homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
26.4 kDa
Protein Accession #:
NP_078902
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q7Z7D3