Clusterin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-191-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CLU, Clusterin, AAG4, APOJ, CLI, KUB1, SGP-2, SP-40, TRPM2
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Clusterin (CLU) is also known as dimeric acidic glycoprotein (DAG protein), testosterone repressed prostate message-2 (TRPM-2), sulfated glycoprotein-2 (SGP-2) and complement lysis inhibitor (CLI), is a secreted multifunctional glycoprotein protein which belongs to the clusterin family. Intracellular cleavages of the precursor of clusterin remove the signal peptide and generate comparably sized α and β chains which are secreted as an 80 kDa N?glycosylated disulfide?linked heterodimer. DAG protein is predominantly expressed in adult testis, ovary, adrenal gland, liver, heart, and brain and in many epithelial tissues during embryonic development. Clusterin involve in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Upregulation of clusterin mRNA and protein levels detected in diverse disease states and in in vitro systems have led to suggestions that it functions in membrane lipid recycling, in apoptotic cell death, and as a stress-induced secreted chaperone protein, amongst others.
Background References:
- Jones SE., et al., Int. J. Biochem. Cell Biol. 34 (5): 427?431.
- Poon S., et al., 2002, J. Biol. Chem. 277:39532-39540.
- Leskov K.S., et al., 2003, J. Biol. Chem. 278:11590-11600.
- Santilli G., et al., 2003, J. Biol. Chem. 278:38214-38219.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
1191
NCBI Official Name:
clusterin
NCBI Official Symbol:
CLU
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
50.9 kDa (Disulfide - linked heterodimer)
Protein Accession #:
NP_001822.3
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P10909