TSP5 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-196-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
COMP, TSP5, EDM1, EPD1, MED, PSACH, THBS5
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Cartilage oligomeric matrix protein (COMP) is also known as Thrombospondin-5 (TSP5), EDM1, EPD1, MED, PSACH, THBS5, which belongs to the thrombospondin family. COMP / TSP5 contains 4 EGF-like domains, 1 TSP C-terminal (TSPC) domain, 8 TSP type-3 repeats. Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. COMP may play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. COMP can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Thrombospondin-5 could play a role in the pathogenesis of osteoarthritis. COMP is a marker of cartilage turnover.
Background References:
- Chen F.-H., et al., 2006, J. Biol. Chem. 280:32655-32661.
- Koelling S., et al., 2006, Arthritis Res. Ther. 8:R56-R56.
- Gagarina V., et al., 2008, J. Biol. Chem. 283:648-659.
- Petersen, G., et al., 2009, Osteoarthritis and Cartilage 18 (1): 34?40.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
1311
NCBI Official Name:
cartilage oligomeric matrix protein
NCBI Official Symbol:
COMP
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
82 kDa
Protein Accession #:
AAI25093
Purity:
>88% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P49747