CAR Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-231-0.1mg | 0.1mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
CXADR, CAR, CAR4/6, HCAR
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human?CXADR?protein contains?a?signal?sequence,?a?extracellular?domain?(ECD)?with?a?V? type?(D1)?and?a?C2? type?(D2)?Ig?like?domain,?a? transmembrane?segment?and?a?intracellular?domain.?D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.
Background References:
- Bergelson JM, et al., 1997, Science 275 (5304): 1320?3.
- Tomko RP, et al., 1997, Proc Natl Acad Sci U S A 94 (7): 3352?6.
- Patzke C, et al., 2010, Journal of Neuroscience 30 (8): 2897?2910.
- Raschperger, E. et al., 2006, Exp. Cell Res. 312: 1566-80.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
1525
NCBI Official Name:
coxsackie virus and adenovirus receptor
NCBI Official Symbol:
CXADR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
24.9 kDa
Protein Accession #:
NP_001329.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P78310