CD26 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-245-0.05mg | 0.05mg | £729.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
DPP4, ADABP, ADCP2, CD26, DPPIV, TP103
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
Background References:
- Kameoka J, et al.,1993, Science, 261 (5120): 466-9.
- Chen X, 2006, Adv. Exp. Med. Biol. 575: 27?32.
- Morimoto, C. et al., 1994, Proc. Natl. Acad. Sci. USA. 91: 9960-4.
- Havre PA, et al., 2008, Front. Biosci. 13: 1634?45.
Biological Activity:
Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin (GPAMC). The specific activity is >3000 pmol/min/μg.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
1803
NCBI Official Name:
dipeptidyl-peptidase 4
NCBI Official Symbol:
DPP4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
85.4 kDa
Protein Accession #:
NP_001926.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P27487