Autotaxin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-264-0.05mg | 0.05mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
ENPP2, E-NPP 2, Autotaxin, LysoPLD, ATX, PDNP2, ATX-X, NPP2, PD-IALPHA
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Autotaxin also known as ectonucleotide pyrophosphatase / phosphodiesterase family member 2 (E-NPP 2 or ENPP2), Extracellular lysophospholipase D (LysoPLD), Autotaxin (ATX or ATX-X), which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP2 contains two SMB (somatomedin-B) domains. ENPP2 hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. ENPP2 can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. ENPP2 stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein.
Background References:
- Stracke M.L., et al., 1992, J. Biol. Chem. 267:2524-2529.
- Nam S.W., et al., 2001, Cancer Res. 61:6938-6944.
- Hausmann J., et al., 2011, Nat. Struct. Mol. Biol. 18:198-204.
Buffer:
50 mM Tris, 150 mM NaCl, pH 7.5
Fusion Tag:
His Tag
NCBI Gene ID #:
5168
NCBI Official Name:
ectonucleotide pyrophosphatase/phosphodiesterase 2
NCBI Official Symbol:
ENPP2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
94.5 kDa
Protein Accession #:
NP_001035181
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q13822