Growth Hormone Receptor Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-350-0.05mg | 0.05mg | £597.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
GHR, GHBP, GH receptor
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
Background References:
- Duquesnoy P., et al., 1994, EMBO J. 13:1386-1395.
- Urbanek M., et al., 1993, J. Biol. Chem. 268:19025-19032.
Biological Activity:
Immobilized Human GH, Tag Free at 2ug/mL (100uL/well) can bind Human GHR, His Tag with a linear range of 1-7.8 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2690
NCBI Official Name:
growth hormone receptor
NCBI Official Symbol:
GHR
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
28.5 kDa
Protein Accession #:
P10912
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P10912