Osteoactivin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-368-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
GPNMB, HGFIN, NMB, Osteoactivin
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Transmembrane glycoprotein NMB (GPNMB) is also known as Transmembrane glycoprotein HGFIN, DC-HIL and Osteoactivin (OA), which belongs to the PMEL/NMB family. GPNMB contains one PKD domain. GPNMB is a transmembrane glycoprotein that is up-regulated in various cancer cells, including in glioblastoma multiforme and is expressed in many melanoma cells, as well as in tissue macrophages. GPNMB protein acts as a downstream mediator of BMP-2 effects on osteoblast differentiation and function. GPNMB participates in bone mineralization, and functions as a negative regulator of inflammation in macrophages.
Background References:
- Weterman MA., et al., 1995, International Journal of Cancer 60 : 73?81.
- Abdelmagid, SM., et al., 2008, Exp Cell Res 314 (13): 2334?51.
- Abdelmagid SM., et al., 2007, J Cell Physiol. 210 (1): 26?37.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
10457
NCBI Official Name:
glycoprotein (transmembrane) nmb
NCBI Official Symbol:
GPNMB
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
52.9 kDa
Protein Accession #:
AAH32783
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q14956