CD124 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-472-0.05mg | 0.05mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IL4R, CD124, IL4RA
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).
Interleukin?4?Receptor (IL4R) also known as CD124, IL4Rα and?BSF?receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-?biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R?can?alternatively?associate?with?IL?13Ra1?to?form?the?type?II?receptor?which?is?responsive?to?both?IL?4?and?IL?13. Interleukin-4 receptor has been shown to interact with SHC1.
Background References:
- Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 : 54?9.
- Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11): 6382?7.
- Hage T., et al., 1999, Cell 97 (2): 271?81.
- Gessner,A. et al., 2000, Immunobiology. 201 (3-4): 285-307.
Biological Activity:
Measured by its ability to inhibit IL?4?dependent proliferation of TF-1 human erythroleukemic cells. Approximately 253 ng/mL of rhIL?4R will inhibit 50% of the biological response due to 0. 2 ng/mL of rhIL-?4.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3566
NCBI Official Name:
interleukin 4 receptor
NCBI Official Symbol:
IL4R
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
24.5 kDa
Protein Accession #:
NP_000409.1
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P24394