LILRB2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-515-0.1mg | 0.1mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
LILRB2, ILT4, LIR2, MIR10, CD85d
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Background References:
- Borges L., et al., 1997, J. Immunol. 159:5192-5196.
- Fanger N.A., et al., 1998, Eur. J. Immunol. 28:3423-3434.
- Shiroishi M., et al., 2003, Proc. Natl. Acad. Sci. U.S.A. 100:8856-8861.
Biological Activity:
Measured by its ability of the immobilized protein to support the adhesion of HSB2 human peripheral blood acute lymphoblastic leukemia cells. When 80000 cells/well are added to LILRB2 coated plates (8. 8μg/mL with 100μL/well), > 40% cells will adhere for 1 hour incubation at 37˚C.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
10288
NCBI Official Name:
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
NCBI Official Symbol:
LILRB2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
48.6 kDa
Protein Accession #:
AAH36827
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q8N423