Serpin E2 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-683-0.025mg | 0.025mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
SERPINE2, Glia-derived nexin, GDN, Peptidase inhibitor 7, PI-7, Protease nexin 1, PN-1, Serpin E2, SerpinE2, PI7
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
SERPINE2 is also known as Glia-derived nexin (GDN), Peptidase inhibitor 7 (PI7), Protease nexin 1(PN1). SERPINE2 is a secreted glycoprotein which belongs to the serpin family. SerpinE1 is the primary physiological inhibitor of the two plasminogen activators urokinase (uPA) and tissue plasminogen activator (tPA). PAI-1 / GDN is also implicated in adipose tissue development. It suggests that PAI-1 inhibitors serve in the control of atherothrombosis. Defects in Serpin E1 / PN1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency) which is characterized by abnormal bleeding due to SerpinE1 defect in the plasma.
Background References:
- Gloor S.M., et al., 1986, Cell 47:687-693.
- Scott R.W., et al., 1985, J. Biol. Chem. 260:7029-7034.
Biological Activity:
Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca - RPKPVE - Nval - WRK(Dnp) - NH2.
Buffer:
20 mM NaAc, 100 mM NaCl, PH6.5
Fusion Tag:
His Tag
NCBI Gene ID #:
5270
NCBI Official Name:
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
NCBI Official Symbol:
SERPINE2
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
42.7 kDa
Protein Accession #:
P07093-2
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P07093