Stathmin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-705-0.1mg | 0.1mg | £524.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
STMN1, Stathmin, C1orf215, LAP18, OP18
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Stathmin (STMN1), a member of the stathmin family, is also known as Leukemia-associated phosphoprotein p18, Oncoprotein 18 (Op18), Phosphoprotein p19 (pp19), Protein Pr22 and pp17, which contains one SLD (stathmin-like) domain. The function of STMN1 as an important regulatory protein of microtubule dynamics has been well-characterized. Stathmin (STMN1) interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex.One mole of STMN1 binds to two moles of tubulin dimers through the stathmin-like domain (SLD).When STMN1 sequesters tubulin into the T2S complex, tubulin becomes non-polymerizable. Without tubulin polymerization, there is no microtubule assembly.STMN1 also promotes microtubule disassembly by acting directly on the microtubule ends.
Background References:
- Jourdain L., et al., 1997, Biochemistry. 36(36):10817-21.
- Rubin CI., et al., 2004, J Cell Biochem. 93(2):242-50.
- Redeker V., et al., 2000, J. Biol. Chem. 275:6841-6849.
Buffer:
PBS, pH 7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
3925
NCBI Official Name:
STMN1
NCBI Official Symbol:
STMN1
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
18.1 kDa
Protein Accession #:
NP_981946
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
E. coli
Swissprot #:
P16949