VEGFD Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-777-0.1mg | 0.1mg | £765.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
FIGF, VEGFD
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Vascular endothelial growth factor D (VEGF-D) is also known as C-fos induced growth factor (FIGF), which belongs to the PDGF / VEGF growth factor family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. This secreted protein VEGF-D / FIGF undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3. The structure and function of this protein is similar to those of VEGFC. FIGF / VEGF-D is highly expressed in lung, heart, small intestine and fetal lung. FIGF / VEGF-D may function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR / FLK1) and VEGFR-3 (FLT4) receptors.
Background References:
- Leppanen V.M., et al., 2011, Blood 117:1507-1515.
- Yamada Y., et al., 1997, Genomics 42 (3): 483?8.
- Achen MG., et al., 1998, Proc. Natl. Acad. Sci. U.S.A. 95 (2): 548?53.
- Yasuoka H., et al., 2005, Mod. Pathol. 18 (8): 1127?33.
Biological Activity:
The bioactivity was measured by its ability to stimulate the cell proliferation of human microvascular endothelial cells (HMVECs). The ED50 for this effect is typically 50-200 ng/mL.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
2277
NCBI Official Name:
c-fos induced growth factor (vascular endothelial growth factor D)
NCBI Official Symbol:
FIGF
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
13 kDa
Protein Accession #:
AAH27948
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
O43915