Neprilysin Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-541-0.05mg | 0.05mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
MME, CALLA, CD10, DKFZp686O16152, MGC126681, MGC126707, NEP, SFE, Neprilysin
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Cluster of differentiation 10 (CD10) is also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, and common acute lymphoblastic leukemia antigen (CALLA), is a 90-110-kDa type II transmembrane glycoprotein normally expressed by a variety of tissues, including epithelial cells of the prostate, kidney, intestine, endometrium, adrenal glands, and lung. This zinc-dependent metalloprotease enzyme cleaves peptide bonds on the amino side of hydrophobic residues and inactivates a variety of physiologically active secreted peptides. CD20 is thought to be the rate-limiting degrading enzyme of amyloid β peptide (Aβ) whose abnormal misfolding and aggregation in neural tissue has been implicated in the development of Alzheimer's disease (AD). CD10 is also identified as the common acute lymphoblastic leukemia antigen (CALLA) present on leukemic cells of pre-B phenotype, and thus serves as the most important biomarker in the diagnosis of human acute lymphocytic leukemia (ALL).
Background References:
- Pardossi-Piquard, et al. 2006, Journal of Neurochemistry 97 (4): 1052?6.
- Goodman, O.B. et al., 2006, J. Biol. Chem. 281: 33597-33605.
- Cohen, A.J. 1996, Cancer. Res. 56: 831-839.
- Shipp, M.A. et al. 1989, Proc. Natl. Acad. Sci. USA. 86: 297-301.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
N-Fc Tag
NCBI Gene ID #:
4311
NCBI Official Name:
membrane metallo-endopeptidase
NCBI Official Symbol:
MME
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
107.3 kDa
Protein Accession #:
NP_000893.2
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P08473