Interleukin 4 Recombinant Protein (HEK293 Expressed)
| Code | Size | Price |
|---|
| PSI-96-443-0.02mg | 0.02mg | £481.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IL4, BCGF1, BSF1
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
Background References:
- Callard RE., et al., 1991, Br J Haematol. Jul;78(3):293-9.
- Varin A, Gordon S., et al., 2009, Immunobiology. 214(7):630-41.
- Finkelman FD, et al., 2004, Immunol Rev. 201:139-55.
- Lee YJ, Jameson SC,et al., 2011, Trends Immunol. 32(2):50-6. Epub 2011 Feb 1.
Biological Activity:
The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50 < 0. 2 ng/mL, corresponding to a specific activity of >5X106 Unit/mg.
Buffer:
20 mM Na2HPO4, 200 mM NaCl, pH7.0
Fusion Tag:
Tag free
NCBI Gene ID #:
3565
NCBI Official Name:
interleukin 4
NCBI Official Symbol:
IL4
NCBI Organism:
Homo sapiens
Physical State:
Lyophilized
Predicted Molecular Weight:
14.9 kDa
Protein Accession #:
AAH67514
Purity:
>90% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P05112