Influenza A virus Neuraminidase Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-372-0.1mg | 0.1mg | £686.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Influenza virus
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
NA, Neuraminidase
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.
Background References:
- Manz B., et al., 2012, Submitted to the EMBL/GenBank/DDBJ databases.
Biological Activity:
Measured by its ability to cleave a fluorogenic substrate, 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid. One unit is defined as the amount of enzyme required to cleave 1 nmole of 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid per minute at pH 7. 5 at 37˚C.
Buffer:
PBS, pH7.4
Fusion Tag:
His Tag
Physical State:
Lyophilized
Predicted Molecular Weight:
46.1 kDa
Protein Accession #:
H8PF47
Purity:
>92% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
H8PF47