CD130 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-477-0.1mg | 0.1mg | £657.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Mouse
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
IL6ST, gp130, CD130, IL-6RB, IL-6R-beta, CDw130
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Interleukin-6 receptor subunit beta (IL6ST) is also known as IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, Interleukin-6 signal transducer, Membrane glycoprotein 130 (gp130), CD130, Oncostatin-M receptor subunit alpha and Il6st,which is single-pass type I membrane protein. IL6ST /gp130 /CD130 can be found in tissues such as brain, heart, thymus, spleen, kidney, lung and liver and found in all the cell lines tested except BaF-B03.The expression of IL-6ST /gp130 is not restricted to IL6-responsive cells. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. IL6ST /CD130 can bind to IL6 /IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduce the signal. IL6ST /GP130 does not bind IL6 and may have a role in embryonic development.
Background References:
- Saito M., et al., 1992, J. Immunol. 148:4066-4071. (2) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386. (3) Tanaka M., et al., 1999, Blood 93:804-815.
- Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
- Tanaka M., et al., 1999, Blood 93:804-815.
Buffer:
Tris?with?Glycine,?Arginine?and?NaCl,?pH7.5
Fusion Tag:
C-Fc Tag
NCBI Gene ID #:
16195
NCBI Official Name:
interleukin 6 signal transducer
NCBI Official Symbol:
Il6st
NCBI Organism:
Mus musculus
Physical State:
Lyophilized
Predicted Molecular Weight:
93.3 kDa
Protein Accession #:
NP_034690
Purity:
>95% as determined by SDS-PAGE.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
Q00560