PCSK9 Recombinant Protein
| Code | Size | Price |
|---|
| PSI-96-585-0.05mg | 0.05mg | £626.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Target Species: Rat
Application: Western Blot (WB)
Storage:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Documents
Further Information
Additional Names:
PCSK9, FH3, HCHOLA3, LDLCQ1, NARC1, PC9
Application Note:
This recombinant protein can be used for WB. For research use only.
Background:
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Background References:
- Seidah NG, et al., Proc. Natl. Acad. Sci. U.S.A. 100 (3): 928?33.
- Abifadel, M. et al., 2003, Nat. Genet. 34: 154-156.
- Dubuc G. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (8): 1454?9.
Buffer:
PBS,pH7.4
Fusion Tag:
His Tag
NCBI Gene ID #:
298296
NCBI Official Name:
proprotein convertase subtilisin/kexin type 9
NCBI Official Symbol:
Pcsk9
NCBI Organism:
Rattus norvegicus
Physical State:
Lyophilized
Predicted Molecular Weight:
73.2 kDa
Protein Accession #:
P59996-1
Purity:
>95% as determined by reduced SDS-PAGE.
Less than 1.0 EU per ug by the LAL method.
Less than 1.0 EU per ug by the LAL method.
Recombinant Protein Sequence:
Thr32-Gly402
Source:
HEK293 cells
Swissprot #:
P59996