IHR-1
| Code | Size | Price |
|---|
| AG-CR1-3526-M001 | 1 mg | £45.00 |
Quantity:
| AG-CR1-3526-M005 | 5 mg | £100.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
Inhibitor of Hedgehog Response 1; N,N'-1,4-Phenylene bis[2,5-dichloro-benzamide
Appearance:
White to grey solid.
CAS:
548779-60-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
Protect from light.
InChi:
InChI=1S/C20H12Cl4N2O2/c21-11-1-7-17(23)15(9-11)19(27)25-13-3-5-14(6-4-13)26-20(28)16-10-12(22)2-8-18(16)24/h1-10H,(H,25,27)(H,26,28)
InChiKey:
VCLHHRGZKNUOAQ-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 548779-60-8. Formula: C20H12Cl4N2O2. MW: 454.1. Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
MDL:
MFCD03404776
Molecular Formula:
C20H12Cl4N2O2
Molecular Weight:
454.1
Package Type:
Vial
Product Description:
Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Purity:
>98% (NMR)
SMILES:
ClC1=CC(C(=O)NC2=CC=C(NC(=O)C3=CC(Cl)=CC=C3Cl)C=C2)=C(Cl)C=C1
Solubility Chemicals:
Soluble in DMSO.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 1 year after receipt when stored at -20°C.
References
The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation: C.W. Fan, et al.; Chem. Biol. 21, 1680 (2014)
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