beta-Mannosylceramide
| Code | Size | Price |
|---|
| AG-CR1-3621-C250 | 250 ug | £160.00 |
Quantity:
| AG-CR1-3621-M001 | 1 mg | £300.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Antibody Isotype: n/a
Antibody Clone: n/a
Regulatory Status: RUO
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternate Names/Synonyms:
beta-ManCer; beta-Mannosyl Ceramide; (2S,3S,4R)-2-Amino-N-hexacosanoyl-1-O-(beta-D-mannopyranosyl)-1,3,4-octadecanetriol
Appearance:
White to off-white solid.
CAS:
1334332-65-8
EClass:
32160000
Form (Short):
liquid
Handling Advice:
After reconstitution, prepare aliquots and store at -20°C.Aliquot into glass vials.
InChi:
InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)/t42-,43+,44+,46-,47+,48-,49-,50+/m0/s1
InChiKey:
VQFKFAKEUMHBLV-JDMIZZMOSA-N
Long Description:
Chemical. CAS: 1334332-65-8. Formula: C50H99NO9. MW: 858.3. Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer (AG-CN2-0014). Does not induce anergy of iNKT cells.
Molecular Formula:
C50H99NO9
Molecular Weight:
858.3
Other data:
Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity. They express T cell receptors (TCR) on their surface consisting of an invariable alpha-chain and a somewhat variable beta-chain. The majority of NKT cells express the invariable alpha-chain Valpha14-Jalpha18 (Valpha14) in mouse or its homolog in humans Valpha24-Jalpha18 (Valpha24). NKT cells expressing the invariant Valpha19-Jalpha26 TCR alpha-chain (Valpha19 NKT cells) have been found in peripheral blood lymphocytes and in the liver.
Package Type:
Vial
Product Description:
Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer (AG-CN2-0014). Does not induce anergy of iNKT cells.
Purity:
>95% (TLC, NMR)
SMILES:
CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](COC1OC(CO)C(O)C(O)C1O)[C@H](O)[C@H](O)CCCCCCCCCCCCCC
Solubility Chemicals:
Soluble in pyridine or warm DMSO. Insoluble in water.
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
Mouse and human iNKT cell agonist beta-mannosylceramide reveals a distinct mechanism of tumor immunity: J.J. O'Konek, et al.; J. Clin. Invest. 121, 683 (2011) | NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma: S.R. Mattarollo, et al.; Blood 120, 3019 (2012) | beta-mannosylceramide activates type I natural killer t cells to induce tumor immunity without inducing long-term functional anergy: J.J. O'Konek, et al.; Clin. Cancer Res. 19, 4404 (2013)