4-Hydroxyphenylpyruvic acid
| Code | Size | Price |
|---|
| CDX-H0013-G001 | 1 g | £59.00 |
Quantity:
| CDX-H0013-G005 | 5 g | £205.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Ambient
Storage:
+4°C
Documents
Further Information
Alternate Names/Synonyms:
3-(4-Hydroxyphenyl)-2-oxopropanoic acid; 4-HPPA; p-Hydroxyphenylpyruvic acid
Appearance:
Light yellow crystalline.
CAS:
156-39-8
EClass:
32160000
Form (Short):
liquid
GHS Symbol:
GHS07
Handling Advice:
Keep cool and dry.Protect from light and moisture.
Hazards:
H315, H319, H335
InChi:
InChI=1S/C9H8O4/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,10H,5H2,(H,12,13)
InChiKey:
KKADPXVIOXHVKN-UHFFFAOYSA-N
Long Description:
Chemical. CAS: 156-39-8. Formula: C9H8O4. MW: 180.16. Synthetic Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
MDL:
MFCD00002591
Molecular Formula:
C9H8O4
Molecular Weight:
180.16
Package Type:
Vial
Precautions:
P261, P305, P351, P338
Product Description:
Keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine.
Purity:
>98% (HPLC)
Signal word:
Warning
SMILES:
OC(=O)C(=O)CC1=CC=C(O)C=C1
Solubility Chemicals:
Soluble in water, ethanol (50 mg/ml), ether or methanol.
Source / Host:
Synthetic
Transportation:
Non-hazardous
UNSPSC Category:
Biochemical Reagents
UNSPSC Number:
12352200
Use & Stability:
Stable for at least 2 years after receipt when stored at -20°C.
References
(1) C.H. Doy, et al.; Nature 186, 529 (1960) | (2) W. Loffelhardt & H. Kindl; FEBS Lett 104, 332 (1979) | (3) K. Tomoeda, et al.; Mol. Genet. Metab. 71, 506 (2000) | (4) E. van Dyk & P. Pretorius; BBRC 338, 815 (2005)